David Duneau

David Duneau

PhD in Evolutionary parasitology

Institute of Evolutionary Biology at Edinburgh Univ.

Biography

Why do some individuals suffer more than others from infection?

I seek to understand why individuals within a given species respond differently to environmental challenges, especially from parasitic organisms. I apply concepts from evolutionary biology to model invertebrates (e.g., Drosophila melanogaster, Daphnia magna), and combine empirical approaches such as controlled infections and functional genetics with statistical modelling, genomics, and transcriptomics to study the role of host, and parasite, evolution in this variation in disease outcome.

Download my CV. Publication list with summaries.

Interests

  • Evolutionary parasitology
  • Infectious diseases
  • Sexual dimorphism
  • Genetic basis of quantitative traits using GWAS
  • Resistance vs disease tolerance
  • Within-host dynamics and evolution

Education

  • PhD student in Evolutionary Parasitology, 2011

    Dieter Ebert's lab, Basel University, Switzerland

  • Master in Ecology and Evolutionary Biology, 2006

    University of Montpellier II, France

  • BSc in Organismal Biology, 2005

    University of Montpellier II, France

Projects

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Sexual dimorphism of diseases

Sexual dimorphism of diseases

Most infectious diseases have a sexually dimorphic outcome. We investigate the reasons for this not only with a host-centered view but also by considering that pathogens adapt to the most commonly encountered sex.

Host manipulation by parasites

Host manipulation by parasites

One of the parasite strategy to increase its transmission is to manipulates its host. I started science by studying such strategy.

Within-host dynamics and disease outcomes

Within-host dynamics and disease outcomes

Infection outcome depends on the success of the parasite within its host. With theoretical and empirical approaches, we study what influences pathogen dynamics and its implication on symptoms.

Sexual selection in parthenogenetic species

Sexual selection in parthenogenetic species

Parthenogenetic species produce mainly daughter without males. We study the selection during the rare event of sexual reproduction.

Mechanism host-parasite coevolution

Mechanism host-parasite coevolution

Parasites need to go through several infection steps to be successfull. We study how the evolution at each step shapes host-parasite coevolution.

Genetic basis of quantitative traits

Genetic basis of quantitative traits

Genetic variation is the raw material for evolution. We pertain to identify, using GWAS and the Drosophila Reference Genetic Panel (DGRP), the genetic basis of various quantitative traits (e.g. phenotypic plasticity, insecticide resistance).

Lyme disease in seabirds

Lyme disease in seabirds

Lyme disease is a major threat in many countries. The bacteria responsible for it is mainly transmitted by ticks feeding on mammals. We studied the role of seabirds as reservoir.

Recent Talk

What makes individuals different facing infections?

Click on the Event above to view the video on Youtube.
What makes individuals different facing infections?

Publications

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